Analyses of damage-associated molecular patterns, particularly biglycan, in cisplatin-induced rat progressive renal fibrosis

نویسندگان

چکیده

Damage-associated molecular patterns (DAMPs) and their receptors (TLR-2 -4) may play important roles in renal fibrosis, of which the pathogenesis is complicated. We used rat lesions induced by a single intraperitoneal injection cisplatin at 6 mg/kg body weigh; consisting tissue damage tubules on days 1 3, further regeneration with inflammation mainly 5 7, interstitial fibrosis 9, 12, 15, 20. Microarray analyses (the commencement inflammation) 9 fibrosis) showed that DAMPs increased more than two-fold relative to control included common extra-cellular matrix (ECM) components such as laminin (Lamc2) fibronectin, heat shock protein family, well fibrinogen, although it was limited analysis; Lamc2, an element basement membrane, be regarded indicator for damaged tubules. In real-time RT-PCR analyses, TLR-2 significantly transiently day 1, whereas TLR-4 almost agreement biglycan (a small leucine-rich proteoglycan ubiquitous ECM component). As M1/M2 macrophages participated lesions, presumably, TLR-4, expressed immune cells, could crucial formation association biglycan.

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ژورنال

عنوان ژورنال: Journal of Toxicologic Pathology

سال: 2023

ISSN: ['1881-915X', '0914-9198']

DOI: https://doi.org/10.1293/tox.2022-0148